SCFAs are produced in higher quantities by Acarbose usage.
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The larger message is a healthy gut microbiome is good for you. A healthy gut microbiome makes more SCFA. A diet with lots of fiber, resistant starch and phytonutrients encourages more good bugs to out compete bad bugs in the gut. Acarbose may help with gut microbiome composition (presumably by sending more food into the bowel for the bugs to eat). Eating celery is also good for you.
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Jerusalem artichoke. My attempt at increasing SCFA. As I read about it, it seemed like a cheat code because it is mostly fructoligosaccharides (sp). Also a complete protein. I’ve eaten a few and they are delicious and a little like a water chestnut. Best in salad.
Grows like crazy. I put them by the road because gravel roads send a cloud of dust every time somebody drives by. These guys were supposed to slow that down.
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How eating fiber->short-chain fatty acid (SCFA) metabolites->anti-cancer effects
Open Access Paper:
Short-chain fatty acid metabolites propionate and butyrate are unique epigenetic regulatory elements linking diet, metabolism and gene expression
The short-chain fatty acids (SCFAs) propionate and butyrate have beneficial health effects, are produced in large amounts by microbial metabolism and have been identified as unique acyl lysine histone marks. To better understand the function of these modifications, we used chromatin immunoprecipitation followed by sequencing to map the genome-wide location of four short-chain acyl histone marks, H3K18pr, H3K18bu, H4K12pr and H4K12bu, in treated and untreated colorectal cancer (CRC) and normal cells as well as in mouse intestines in vivo. We correlate these marks with open chromatin regions and gene expression to access the function of the target regions. Our data demonstrate that propionate and butyrate bind and act as promoters of genes involved in growth, differentiation and ion transport. We propose a mechanism involving direct modification of specific genomic regions by SCFAs resulting in increased chromatin accessibility and, in the case of butyrate, opposing effects on the proliferation of normal versus CRC cells.
https://www.nature.com/articles/s42255-024-01191-9
Paywalled paper:
https://www.nature.com/articles/s42255-024-01186-6
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Acarbose increases SCFA as well. This is probably one of the mechanisms as to why mice (little cancer factories) live longer when taking Acarbose + Rapamycin.
Acarbose sends glucose to the colon, which feeds all bacteria and when present there the bad guys do well. This is according to papers I have read about XOS. Xos feeds only the lacto, bifido, and a couple other good guys, but does not feed the bad guys. I wonder if that’s why acarbose causes so much discomfort, while the xos really doesn’t. I’ve had a tub full now and there is really no side effect so far.
Amazing paper…amazing product.
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Notice on this site:
Price barely moves when you go from 100 to 500. You want to buy the big bags…most of the cost is putting it into the bag and sending it to you.
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And inulin is also a good product class for SCFA:
and