Extending the benefit of sleep: Oxygen increase while sleeping

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I wrote some notes on increasing Oxygen while sleeping, as it sounds a possible promising passive biohacking worth the effort Increasing oxygen while sleeping? – Hacking Biology .

While i’ve started from this research on the improve of Oxygen increase while sleeping i’ve dig into the topic, whereby seems a lot of people with sleep apnea problems end-up supplement oxygen to improve their sleep.

I’ve just researched the way to make it “accessible” in a non-invasive way (who want to sleep with a mask?), in order to starts experimenting it.

Did anyone already engaged in supplementing oxygen while sleeping?

Fabio
Hacking Biology project


Chronic hyperoxia does cause harm. Where the threshold is on this I don’t know. Short periods of hyperoxia (such as in HBOT) are ok.

I wrote about this here:



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Definitively there are risks with too much hyperoxia, and HBOT at 2 ATA for 90min is surely a top things todo (i’m looking to convince local HBOT center to do the alternating hyperoxia/hypoxia protocol), increasing by 10x/15x the oxygen plasma concentration for a while.

Still it’s interesting to analyze what we can do passively while sleeping, so i ended up analyzing the work being done by medicine on those afflicted by obstructive sleep apnoea (OSA), that without the extra oxygen would be in hypoxia condition leading to a lot of sleep and metabolic problems.

Most of those goes with a mask or cannula to sleep, while this product seems to be very interesting in the ergonomics / accessibility:

So i am wondering, in a normobaric pressure during the 7-8h of sleep, what would be a reasonable oxygen supplementation given the effect in increasing NREM / deep sleep phase of the research above, without leading any toxicity effects?

Fabio

Best to read my blog post which gives a tool to compare hyperoxic exposures. Definitely avoid stimulating nf kappa b, personally i would stick to hif 1 alpha and avoid levels that stimulate nrf2