Can statins be pro-healthspan/longevity even if they don’t increase mice lifespan? Interaction with metformin / rapamycin/ etc?

The effects are exponential so those 5 or 10 years are worth much more doing it now than later and even small changes make huge differences.
Ezetimibe won’t affect desmosterol, neither will bempedoic acid or PCKS9i.

Praluent can be had for $200 a month now at 150 mg one time a month.

Ezetimibe is dirt cheap.

I’ve posted some studies a while ago that showed that pulsed (once weekly dose) of statins is quite effective in reducing LDL-C and ApoB. If you add daily Ezetimibe or enough soluble fibers to your diet you can further reduce it.

My apoB last time on 10 mg ezetimibe was 84, I think a small dose of rosuvastatin will be enough for now.

Is Praluent better than Repatha? 150mg of Praluent once a month seems to be an off-label use, right? Does anyone have experience with whether the effectiveness declines too much during the last week? I’m personally interested in PCSK9 inhibitors because statins cause muscle symptoms for me, and Bempedoic Acid caused stomach pain. I’m currently only on Ezetimibe. I have high Lp(a), so in that sense, a PCSK9 inhibitor could be a good option. It might be difficult to get a prescription, and the cost is also a bit intimidating, which is why the 150mg per month option interests me

Has anyone here actually tried the method below? I would appreciate more detailed instructions.

I have just attempted it and while l will put out the caveat that it could certainly be me… I failed miserably (2 injectors wasted). I had difficulty with the needle centering in the syringe(any suggestions would be welcomed). My next attempt will be into a 2 ml sterile vial.

Into a syringe or vial works fine. I’ve done is a dozen times plus – no issues. There is no possibility of wasting the drug if you go through the procedure correctly.

I showed the process of doing this on a video.

I don’t know where the link is now, but @RapAdmin can likely update on this as it was uploaded. Regardless of what autoinjector – if you need to split doses, if can be done.

I was looking for the video you posted too but my search skills are not as good as l had hoped. I found a couple of videos on YouTube and it seemed pretty straightforward… Obviously l was doing something wrong, just not sure what.

A video would be awesome!

I think this is the link.

Thank you very much, @DrFraser !

I’m 39 and take 5mg Rosuvastatin daily. My ApoB was usually 90 before I started both that and 10mg Ezetimibe. Now it’s 40 or less.

If your ApoB is 90, it doesn’t matter how old you are. You should get an early start on getting it under 60. I really don’t see any downside. I am generally all for having an aggressive approach.

It seems so, there was at least a post-hoc analysis detecting an improvement in ACM in its clinical trial compared to Repatha. I don’t remember the effect right before the next dose, but 150 mg Q4W (monthly), at least had at one point a potent effect, and yes it’d be off-label or something like that. Splitting the dosing as others explain could be an option if done sterile.

@RapAdmin thanks for finding the video. I think l see the steps where l failed.

4th time a charm… It’s hard to be me.

How large of a pulsed dose?

If I remember correctly studies were done with atorvastatin (10 and 20 mg) and rosuvastatin (5 and 10 mg) and reduction was about 15-20% with once weekly dose. Will try to find the studies and post them.